Nicholas J. Maness

Sep 16, 2024 | nature.com | Chenxiao Wang |Calder Ellsworth |Nicholas J. Maness |Robert Blair |Jay Kolls |Janet E. Mccombs

AbstractToll-like receptor 7 (Tlr7) deficiency-accelerated severe COVID-19 is associated with reduced production of interferons (IFNs). However, the underlying mechanisms remain elusive. To address these questions, we utilize Tlr7 and Irf7 deficiency mice, single-cell RNA analysis together with bone marrow transplantation approaches. We demonstrate that at the early phase of infection, SARS-CoV-2 causes the upregulation of Tlr7, Irf7, and IFN pathways in the lungs of the infected mice.

Aug 20, 2024 | nature.com | Clovis S. Palmer |Chrysostomos Perdios |Mohamed Abdel-Mohsen |Nicholas J. Maness |Nadia Golden |Kelsey Williams | +4 more

AbstractHyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models. Here, we report a non-human primate model of metabolic post-acute sequelae of SARS-CoV-2 using SARS-CoV-2 infected African green monkeys.

Jul 18, 2024 | nature.com | David Morrow |Andrea Selseth |Lina Gao |Jennifer Tisoncik-Go |Leanne Whitmore |Pyone P. Aye | +6 more

AbstractAn influenza vaccine approach that overcomes the problem of viral sequence diversity and provides long-lived heterosubtypic protection is urgently needed to protect against pandemic influenza viruses.

Dec 12, 2023 | nature.com | Chenxiao Wang |Zhe Zhang |Xiao-Ming Yin |Nicholas J. Maness |Robert Blair |Jay Kolls | +1 more

AbstractSARS-CoV-2 infection can cause persistent respiratory sequelae. However, the underlying mechanisms remain unclear. Here we report that sub-lethally infected K18-human ACE2 mice show patchy pneumonia associated with histiocytic inflammation and collagen deposition at 21 and 45 days post infection (DPI).