Chuanjun Zhuo

Sep 29, 2024 | nature.com | Chuanjun Zhuo

AbstractThe treatment of cognitive impairment in schizophrenia is an unaddressed need due to the absence of novel treatments. Recent studies demonstrated that fingolimod and siponimod have neuroprotective effects in several neuropsychiatric disorders; however, their pharmacological mechanisms are unclear. The objective of this study was to identify potential molecular mechanisms of fingolimod and siponimod for improving cognition of schizophrenia through network pharmacology and molecular docking.

Oct 14, 2023 | nature.com | Chuanjun Zhuo

AbstractThis study was conducted to investigate the effects of long-term low-dose lithium adjunct to antipsychotic agent use on the cognitive performance, whole-brain gray-matter volume (GMV), and interleukin-6 (IL-6) level in drug-naive patients with first-episode schizophrenia, and to examine relationships among these factors.

Jul 26, 2023 | frontiersin.org | Chuang Liu |Jingjing Gao |Chuanjun Zhuo |Shan Sun

Jing Shen1† Qiang Wang1† Fengquan Lu1† Hua Xu1† Peng Wang2† Yu Feng1,3,4*† 1Medical laboratory, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, China 2Suzhou Key Laboratory of Neuro-Oncology and Nano-Bionics, Suzhou, China 3Medicine and Health, The University of New South Wales, Kensington, NSW, Australia 4Melbourne Medical School, The University of Melbourne, Parkville, VIC, Australia Background: The shortened life expectancy in schizophrenia (SCZ) patients may...

Jul 10, 2023 | nature.com | Chuanjun Zhuo

AbstractCognitive impairment is a core clinical feature of schizophrenia, exerting profound adverse effects on social functioning and quality of life in a large proportion of patients with schizophrenia. However, the mechanisms underlying the pathogenesis of schizophrenia-related cognitive impairment are not well understood. Microglia, the primary resident macrophages in the brain, have been shown to play important roles in psychiatric disorders, including schizophrenia.

May 5, 2023 | nature.com | Dominic B. Dwyer |Alessandro Pigoni |Junhao Wen |Gyujoon Hwang |Guray Erus |René S. Kahn | +11 more

AbstractUsing machine learning, we recently decomposed the neuroanatomical heterogeneity of established schizophrenia to discover two volumetric subgroups—a ‘lower brain volume’ subgroup (SG1) and an ‘higher striatal volume’ subgroup (SG2) with otherwise normal brain structure.