Chuchu Wang

Jul 1, 2024 | nature.com | Chuchu Wang |Chunyu Zhao |Yaoyang Zhang |Jacqueline Burré |Yanshan Fang |Cong Liu | +2 more

Abstractα-Synuclein (α-Syn) aggregation is closely associated with Parkinson’s disease neuropathology. Physiologically, α-Syn promotes synaptic vesicle (SV) clustering and soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly. However, the underlying structural and molecular mechanisms are uncertain and it is not known whether this function affects the pathological aggregation of α-Syn.

Mar 8, 2024 | biorxiv.org | Chuchu Wang |Chunyu Zhao |Hu Xiao |Jiali Qiang

AbstractPost-translational modifications (PTMs) of α-synuclein (α-syn) such as acetylation and phosphorylation play important yet distinct roles in regulating α-syn conformation, membrane binding, and amyloid aggregation. However, how PTMs regulate α-syn function in presynaptic terminals remains unclear. Previously, we reported that α-syn clusters synaptic vesicles (SV) 1, and neutral phospholipid lysophosphatidylcholine (LPC) can mediate this clustering 2.

Feb 27, 2024 | buffalonews.com | Chuchu Wang

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Nov 17, 2023 | mdpi.com | Hailong Wu |Chuchu Wang |Jiang Chen |Jiankai Zhang

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