Yanshan Fang

Jul 1, 2024 | nature.com | Chuchu Wang |Chunyu Zhao |Yaoyang Zhang |Jacqueline Burré |Yanshan Fang |Cong Liu | +2 more

Abstractα-Synuclein (α-Syn) aggregation is closely associated with Parkinson’s disease neuropathology. Physiologically, α-Syn promotes synaptic vesicle (SV) clustering and soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly. However, the underlying structural and molecular mechanisms are uncertain and it is not known whether this function affects the pathological aggregation of α-Syn.