Jacqueline Burré

Jul 1, 2024 | nature.com | Chuchu Wang |Chunyu Zhao |Yaoyang Zhang |Jacqueline Burré |Yanshan Fang |Cong Liu | +2 more

Abstractα-Synuclein (α-Syn) aggregation is closely associated with Parkinson’s disease neuropathology. Physiologically, α-Syn promotes synaptic vesicle (SV) clustering and soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly. However, the underlying structural and molecular mechanisms are uncertain and it is not known whether this function affects the pathological aggregation of α-Syn.

Jun 30, 2024 | movementdisorders.onlinelibrary.wiley.com | Jacqueline Burré |Robert Edwards |Glenda M Halliday |Anthony E Lang

α-Synuclein (αSyn) pathology is a major feature of Parkinson's disease (PD), and the occurrence of pathogenic variants in the SNCA gene1-12 or multiplication of its locus13, 14 supports a possible causative role of αSyn in PD. Yet the nature of this role has long been a matter of debate due to unclear αSyn-mediated mechanisms of cell dysfunction, degeneration, and death.