Chunhe Li

Nov 18, 2024 | journals.plos.org | Haochi Zhang |Inner Mongolia |Chunhe Li |Shouxin Sheng |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Zhang H, Sheng S, Li C, Bao X, Zhao L, Chen J, et al. (2024) Mucosal immunization with the lung Lactobacillus-derived amphiphilic exopolysaccharide adjuvanted recombinant vaccine improved protection against P. aeruginosa infection. PLoS Pathog 20(11): e1012696.

Nov 7, 2024 | pubs.acs.org | Tao Zhu |Chunhe Li |Xiakun Chu |Eileen E. M

Precise spatiotemporal regulation of gene expression patterns is governed by DNA regulatory elements, particularly enhancers. (1−4) Enhancers can initiate transcription by activating target gene promoters, which are often located thousands to millions of base pairs away. (5,6) It is well established that these distantly separated enhancers and promoters in the 1D genomic sequence must come into close proximity in 3D nuclear space for gene expression.

Sep 1, 2024 | biorxiv.org | Tao Zhu |Chunhe Li |Xiakun Chu

AbstractEnhancers regulate gene expression by forming contacts with distant promoters. Phase-separated condensates or clusters formed by transcription factors (TFs) and co-factors are thought to facilitate these enhancer-promoter (E-P) interactions. Using polymer physics, we developed distinct coarse-grained chromatin models that produce similar ensemble-averaged Hi-C maps but with "stable" and "dynamic" characteristics.

Mar 7, 2024 | nature.com | Chunhe Li

AbstractThe evolution of cancer is a complex process characterized by stable states and transitions among them. Studying the dynamic evolution of cancer and revealing the mechanisms of cancer progression based on experimental data is an important topic. In this study, we aim to employ a data-driven energy landscape approach to analyze the dynamic evolution of cancer. We take Kidney renal clear cell carcinoma (KIRC) as an example.