Eileen E. M

Nov 7, 2024 | pubs.acs.org | Tao Zhu |Chunhe Li |Xiakun Chu |Eileen E. M

Precise spatiotemporal regulation of gene expression patterns is governed by DNA regulatory elements, particularly enhancers. (1−4) Enhancers can initiate transcription by activating target gene promoters, which are often located thousands to millions of base pairs away. (5,6) It is well established that these distantly separated enhancers and promoters in the 1D genomic sequence must come into close proximity in 3D nuclear space for gene expression.