Clare Puttick

Oct 31, 2024 | digitalcommons.library.tmc.edu | Carlos Martinez-Ruiz |Clare Puttick |Mark Hill |Jonas Demeulemeester

AbstractIntratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy1. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell lung cancer tumours from 347 out of the first 421 patients prospectively recruited into the TRACERx study2,3.