Jonas Demeulemeester

Oct 31, 2024 | digitalcommons.library.tmc.edu | David O'Connor |Jonas Demeulemeester |Lucia Conde |Amy A Kirkwood

PURPOSE: Failure to respond to induction chemotherapy portends a poor outcome in childhood acute lymphoblastic leukemia (ALL) and is more frequent in T-cell ALL (T-ALL) than B-cell ALL. We aimed to address the limited understanding of clinical and genetic factors that influence outcome in a cohort of patients with T-ALL induction failure (IF).

Oct 31, 2024 | digitalcommons.library.tmc.edu | Carlos Martinez-Ruiz |Clare Puttick |Mark Hill |Jonas Demeulemeester

AbstractIntratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy1. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell lung cancer tumours from 347 out of the first 421 patients prospectively recruited into the TRACERx study2,3.