Colin M. Muir

Feb 27, 2025 | scholarsarchive.byu.edu | Katie Pennington |Colten M. McEwan |James Woods |Colin M. Muir

PTOV1, oncoprotein, prostate cancer, 14-3-3 protein, SGK2 phosphorylation, protein-protein interactions, cell proliferation, cancer progression, proteasomal degradation, E3 ubiquitin ligase (HUWE1), cytosolic sequestration, cJun expression, cell-cycle regulationPennington KL, McEwan CM, Woods J, Muir CM, Pramoda Sahankumari AG, Eastmond R, Balasooriya ER, Egbert CM, Kaur S, Heaton T†, McCormack KK, Piccolo SR, Kurokawa M, Andersen J.

Dec 6, 2023 | cell.com | Colin M. Muir |Yann Le Guen |Institut du Cerveau |Stefano E. Rensi

Highlights•Iron elevation causes inward mitochondrial Ca2+ overflow via an Fe2+-MCU interaction•In PD neurons, this Fe2+-Ca2+ signal causes Ca2+ elevation at the OMM•OMM Ca2+ levels are sensed by Miro1•Miro1-based drug screens in PD cells identify Ca2+-channel blockersSummaryDysregulated iron or Ca2+ homeostasis has been reported in Parkinson’s disease (PD) models. Here, we discover a connection between these two metals at the mitochondria.