Stefano E. Rensi

Dec 6, 2023 | cell.com | Colin M. Muir |Yann Le Guen |Institut du Cerveau |Stefano E. Rensi

Highlights•Iron elevation causes inward mitochondrial Ca2+ overflow via an Fe2+-MCU interaction•In PD neurons, this Fe2+-Ca2+ signal causes Ca2+ elevation at the OMM•OMM Ca2+ levels are sensed by Miro1•Miro1-based drug screens in PD cells identify Ca2+-channel blockersSummaryDysregulated iron or Ca2+ homeostasis has been reported in Parkinson’s disease (PD) models. Here, we discover a connection between these two metals at the mitochondria.