Cong-Dat Pham

Oct 8, 2024 | digitalcommons.library.tmc.edu | Jillian E Milanes |Victoria Yan |Cong-Dat Pham |Florian L. Muller |Florian Müller

AbstractInfections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality rate remains >95% in the US. Glycolysis is very important for the infectious trophozoite lifecycle stage and inhibitors of glucose metabolism have been found to be toxic to the pathogen.

May 20, 2024 | digitalcommons.library.tmc.edu | Victoria Yan |Cong-Dat Pham |Kristine Yang |Elliot S Ballato

Cancers harboring homozygous deletion of the glycolytic enzyme enolase 1 (ENO1) are selectively vulnerable to inhibition of the paralogous isoform, enolase 2 (ENO2).

Jan 17, 2024 | biorxiv.org | Jillian E Milanes |Victoria Yan |Cong-Dat Pham |Florian L. Muller |Florian Müller

AbstractInfections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality rate remains >95% in the US. Glycolysis is very important for the infectious trophozoite lifecycle stage and inhibitors of glucose metabolism have been found to be toxic to the pathogen.