Jillian E Milanes

Oct 8, 2024 | digitalcommons.library.tmc.edu | Colm P. Roster |Danielle LaVigne |Jillian E Milanes |Emily Knight

Glucose metabolism is critical for the African trypanosome, Trypanosoma brucei, serving as the lone source of ATP production for the bloodstream form (BSF) parasite in the glucose-rich environment of the host blood. Recently, phosphonate inhibitors of human enolase (ENO), the enzyme responsible for the interconversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP) in glycolysis or PEP to 2-PG in gluconeogenesis, have been developed for the treatment of glioblastoma multiforme (GBM).

Oct 8, 2024 | digitalcommons.library.tmc.edu | Jillian E Milanes |Victoria Yan |Cong-Dat Pham |Florian L. Muller |Florian Müller

AbstractInfections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality rate remains >95% in the US. Glycolysis is very important for the infectious trophozoite lifecycle stage and inhibitors of glucose metabolism have been found to be toxic to the pathogen.

Jan 17, 2024 | biorxiv.org | Jillian E Milanes |Victoria Yan |Cong-Dat Pham |Florian L. Muller |Florian Müller

AbstractInfections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality rate remains >95% in the US. Glycolysis is very important for the infectious trophozoite lifecycle stage and inhibitors of glucose metabolism have been found to be toxic to the pathogen.