Victoria Yan

Oct 8, 2024 | digitalcommons.library.tmc.edu | Jillian E Milanes |Victoria Yan |Cong-Dat Pham |Florian L. Muller |Florian Müller

AbstractInfections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality rate remains >95% in the US. Glycolysis is very important for the infectious trophozoite lifecycle stage and inhibitors of glucose metabolism have been found to be toxic to the pathogen.

Sep 12, 2024 | brookings.edu | Wendy Edelberg |Victoria Yan |Jimmy Zheng

In recent years, The Hamilton Project has tracked the changing state of household finances. In this piece, we provide data interactives for key economic indicators for consumer spending, income, and wealth by business cycle. We highlight the 2020 business cycle (in orange) relative to the seven most recent business cycles (from 1960 through the Great Recession, in green and purple). We find that:Consumer spending has been solid, primarily driven by robust goods spending.

Jun 26, 2024 | digitalcommons.library.tmc.edu | Victoria Yan |Yasaman Barekatain |Yu-Hsi Lin |Nikunj Satani

Metabolically labile prodrugs can experience stark differences in catabolism incurred by the chosen route of administration. This is especially true for phosph(on)ate prodrugs, in which successive promoiety removal transforms a lipophilic molecule into increasingly polar compounds.

May 20, 2024 | digitalcommons.library.tmc.edu | Victoria Yan |Cong-Dat Pham |Kristine Yang |Elliot S Ballato

Cancers harboring homozygous deletion of the glycolytic enzyme enolase 1 (ENO1) are selectively vulnerable to inhibition of the paralogous isoform, enolase 2 (ENO2).

Jan 17, 2024 | biorxiv.org | Jillian E Milanes |Victoria Yan |Cong-Dat Pham |Florian L. Muller |Florian Müller

AbstractInfections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality rate remains >95% in the US. Glycolysis is very important for the infectious trophozoite lifecycle stage and inhibitors of glucose metabolism have been found to be toxic to the pathogen.