Constantin Diekmann

Apr 23, 2024 | nature.com | Luuk Harbers |Michele Simonetti |Constantin Diekmann |Enrico Berrino |Silvia Giordano |Anna Sapino | +7 more

AbstractSomatic copy number alterations (SCNAs) are pervasive in advanced human cancers, but their prevalence and spatial distribution in early-stage, localized tumors and their surrounding normal tissues are poorly characterized. Here, we perform multi-region, single-cell DNA sequencing to characterize the SCNA landscape across tumor-rich and normal tissue in two male patients with localized prostate cancer.

Nov 11, 2023 | biorxiv.org | Ning Zhang |Luuk Harbers |Michele Simonetti |Constantin Diekmann

AbstractSomatic copy number alterations (SCNAs) are pervasive in advanced human cancers, but their prevalence and spatial distribution in early-stage, localized tumors and their surrounding normal tissues are poorly characterized. Here, we performed multi-region, single-cell DNA sequencing to characterize the SCNA landscape across multiple tumor-rich and normal tissue regions (~125 mm3 tissue cubes) obtained from prostatectomy performed in two patients with localized prostate cancer.