Anna Sapino

Nov 29, 2024 | translational-medicine.biomedcentral.com | Alessia Andrea |Alessia Ricci |Gabriele Roccuzzo |Luca Bertero |Enrico Berrino |Valentina Pala | +10 more

Out of 32 patients, 15 (46.9%) were males and 17 (53.1%) were females, with a median age at diagnosis of 50 years (range: 32–80). All patients were diagnosed with stage III CM, mostly affecting the trunk (59.4%), limbs (34.4%), and head/neck (6.2%). Lymph node involvement was observed in 29/32 patients (90.6%). Basal lactate dehydrogenase (LDH) levels (normal range 250–450 UI/L) ranged from 231 to 543 UI/L in the cohort, with a median LDH level of 346 UI/L.

Nov 29, 2024 | translational-medicine.biomedcentral.com | Alessia Andrea |Alessia Ricci |Gabriele Roccuzzo |Luca Bertero |Enrico Berrino |Valentina Pala | +10 more

Out of 32 patients, 15 (46.9%) were males and 17 (53.1%) were females, with a median age at diagnosis of 50 years (range: 32–80). All patients were diagnosed with stage III CM, mostly affecting the trunk (59.4%), limbs (34.4%), and head/neck (6.2%). Lymph node involvement was observed in 29/32 patients (90.6%). Basal lactate dehydrogenase (LDH) levels (normal range 250–450 UI/L) ranged from 231 to 543 UI/L in the cohort, with a median LDH level of 346 UI/L.

Apr 23, 2024 | nature.com | Luuk Harbers |Michele Simonetti |Constantin Diekmann |Enrico Berrino |Silvia Giordano |Anna Sapino | +7 more

AbstractSomatic copy number alterations (SCNAs) are pervasive in advanced human cancers, but their prevalence and spatial distribution in early-stage, localized tumors and their surrounding normal tissues are poorly characterized. Here, we perform multi-region, single-cell DNA sequencing to characterize the SCNA landscape across tumor-rich and normal tissue in two male patients with localized prostate cancer.