Corey Speers

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Reply to Y. Wang et al and Q. Sui et al

Jun 1, 2023 | ascopubs.org | Corey Speers |William E. Barlow |W. Fraser Symmans

We appreciate the interest of Sui et al1 in our recent report2 and agree that SET 2,3 and many other tumor biomarker tests rely on averaged gene expression from a mixed population of cells, including malignant tumor cells, tumor-associated immune cells, stromal tissue, and endothelial cells. These tests, of necessity, are unable to get at the spatial and microenvironment-related heterogeneity that exists.

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