W. Fraser Symmans

Sep 13, 2024 | nature.com | Rita Nanda |Hope Rugo |Judy Boughey |Kevin Kalinsky |Christos Vaklavas |Claudine Isaacs | +8 more

AbstractSequential adaptive trial designs can help accomplish the goals of personalized medicine, optimizing outcomes and avoiding unnecessary toxicity.

Aug 20, 2024 | nature.com | Daniel G. Stover |Roberto Salgado |Sherene Loi |W. Fraser Symmans |Charles M. Perou |Lisa Carey

AbstractAssociation of stromal tumor-infiltrating lymphocytes (sTILs) with survival outcomes among patients with metastatic breast cancer (MBC) remains unclear. The primary objective was to evaluate the association of sTILs with progression-free survival in randomized phase III trial CALGB 40502.

May 26, 2024 | nature.com | Reid T. Powell |Amanda Rinkenbaugh |Xiaomei Zhang |Yuan Qi |Clifford Stephan |Peter J Davies | +2 more

AbstractTriple negative breast cancer (TNBC) accounts for 15–20% of breast cancer cases in the United States. Systemic neoadjuvant chemotherapy (NACT), with or without immunotherapy, is the current standard of care for patients with early-stage TNBC. However, up to 70% of TNBC patients have significant residual disease once NACT is completed, which is associated with a high risk of developing recurrence within two to three years of surgical resection.

Jun 1, 2023 | ascopubs.org | Corey Speers |William E. Barlow |W. Fraser Symmans

We appreciate the interest of Sui et al1 in our recent report2 and agree that SET 2,3 and many other tumor biomarker tests rely on averaged gene expression from a mixed population of cells, including malignant tumor cells, tumor-associated immune cells, stromal tissue, and endothelial cells. These tests, of necessity, are unable to get at the spatial and microenvironment-related heterogeneity that exists.

May 25, 2023 | nature.com | W. Fraser Symmans

AbstractPublications comparing variant caller algorithms present discordant results with contradictory rankings. Caller performances are inconsistent and wide ranging, and dependent upon input data, application, parameter settings, and evaluation metric. With no single variant caller emerging as a superior standard, combinations or ensembles of variant callers have appeared in the literature.