Cristina Olivieri

Jun 24, 2024 | elifesciences.org | Byrne DP |Cristina Olivieri |Yingjie Wang |Caitlin Walker

eLife assessment This important study provides an example of integrating computational and experimental approaches that lead to new insights into the energy landscape of a model kinase. Compelling use of molecular dynamics simulations and NMR spectroscopy provide a conformational description of active and excited states of the kinase; one of which has not been captured in previously solved crystal structures.

Sep 15, 2023 | biorxiv.org | Cristina Olivieri |Yingjie Wang |Caitlin Walker |Manu Veliparambil Subrahmanian

AbstractAllosteric cooperativity between ATP and substrates is a prominent characteristic of the cAMP-dependent catalytic (C) subunit of protein kinase A (PKA). Not only this long-range syn-ergistic action is involved in substrate recognition and fidelity, but it is likely to regulate PKA as-sociation with regulatory subunits and other binding partners. To date, a complete understanding of the molecular determinants for this intramolecular mechanism is still lacking.