Curdin Conrad

Nov 7, 2024 | emjreviews.com | Khaled Ezzedine |Albert Wolkerstorfer |Curdin Conrad |Markus Böhm

INTRODUCTIONVitiligo is a chronic autoimmune disease caused by a deregulation of the immune response that results in epidermal melanocyte destruction.1 With a variable and unpredictable disease course consisting of stable periods, spontaneous re-pigmentation, and new patches or flares, it should no longer be considered a cosmetic disease.

Jul 31, 2024 | jamanetwork.com | Andrew Blauvelt |Blauvelt Consulting |Lake Oswego |Curdin Conrad

Extending Maintenance Dosing Intervals for Guselkumab in the Treatment of Patients With Psoriasis 16-Week vs 8-Week Guselkumab Dosing in Super Responders for Control of Psoriasis Kilian Eyerich, MD; Khusru Asadullah, MD; Andreas Pinter, MD; Peter Weisenseel, MD; Kristian Reich, MD; Carle Paul, MD; Robert Sabat, MD; Kerstin Wolk, PhD; Stefanie Eyerich, PhD; Felix Lauffer, MD; Julianty Angsana, PhD; Friedemann J. H.

Jun 30, 2023 | nature.com | François Kuonen |Nadine Fournier |Feiyang Ma |Johann E. Gudjonsson |Lennart M. Roesner |Curdin Conrad | +2 more

AbstractInterleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 responses is unknown. Here we identify a population of blood TH17 intermediates that produce high levels of IL-26 and differentiate into IL-17A-producing TH17 cells upon TGF-β1 exposure. By combining single cell RNA sequencing, TCR sequencing and spatial transcriptomics we show that this process occurs in psoriatic skin.