François Kuonen

Jun 30, 2023 | nature.com | François Kuonen |Nadine Fournier |Feiyang Ma |Johann E. Gudjonsson |Lennart M. Roesner |Curdin Conrad | +2 more

AbstractInterleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 responses is unknown. Here we identify a population of blood TH17 intermediates that produce high levels of IL-26 and differentiate into IL-17A-producing TH17 cells upon TGF-β1 exposure. By combining single cell RNA sequencing, TCR sequencing and spatial transcriptomics we show that this process occurs in psoriatic skin.