François Kuonen

1 month ago | nature.com | Helen Hope |Pierpaolo Ginefra |Massimo Andreatta |Christine Pich-Bavastro |Jesús Corria Osorio |François Kuonen | +4 more

AbstractChimeric antigen receptor (CAR) T cell therapy is one of the most promising cancer treatments. However, different hurdles are limiting its application and efficacy. In this context, how aging influences CAR-T cell outcomes is largely unknown. Here we show that CAR-T cells generated from aged female mice present a mitochondrial dysfunction derived from nicotinamide adenine dinucleotide (NAD) depletion that leads to poor stem-like properties and limited functionality in vivo.

Jun 30, 2023 | nature.com | François Kuonen |Nadine Fournier |Feiyang Ma |Johann E. Gudjonsson |Lennart M. Roesner |Curdin Conrad | +2 more

AbstractInterleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 responses is unknown. Here we identify a population of blood TH17 intermediates that produce high levels of IL-26 and differentiate into IL-17A-producing TH17 cells upon TGF-β1 exposure. By combining single cell RNA sequencing, TCR sequencing and spatial transcriptomics we show that this process occurs in psoriatic skin.