Lennart M. Roesner

Jul 14, 2024 | medrxiv.org | Shruti Tripathi Chopra |Lennart M. Roesner |Katinka Döhner |Jana Zeitvogel

The authors have declared no competing interest. This study was funded by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germanys Excellence Strategy-EXC 2155 RESIST- project number 390874280. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Jun 30, 2023 | nature.com | François Kuonen |Nadine Fournier |Feiyang Ma |Johann E. Gudjonsson |Lennart M. Roesner |Curdin Conrad | +2 more

AbstractInterleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 responses is unknown. Here we identify a population of blood TH17 intermediates that produce high levels of IL-26 and differentiate into IL-17A-producing TH17 cells upon TGF-β1 exposure. By combining single cell RNA sequencing, TCR sequencing and spatial transcriptomics we show that this process occurs in psoriatic skin.