Dan Xie

Oct 28, 2024 | nature.com | Dan Xie

AbstractOxaliplatin-based therapeutics is a widely used treatment approach for hepatocellular carcinoma (HCC) patients; however, drug resistance poses a significant clinical challenge. Epigenetic modifications have been implicated in the development of drug resistance. In our study, employing siRNA library screening, we identified that silencing the m6A writer METTL3 significantly enhanced the sensitivity to oxaliplatin in both in vivo and in vitro HCC models.

Oct 15, 2024 | cell.com | Sun Yat-sen |Johns Hopkins |Dan Xie |Yuan Lin

Keywordscolorectal cancercolorectal neuroendocrine tumordeep learningfoundation modelmultimodal fusionpathological knowledgeIntroductionNeuroendocrine tumors (NETs) are a group of rare neoplasms originating from neuroendocrine cells throughout the body, known for producing peptide hormones and biogenic amines.1,2,3 The gastrointestinal tract is the most common site of NET occurrence.

Jun 11, 2024 | onlinelibrary.wiley.com | Ying Xian |Dan Xie |Jian Zhu

1 INTRODUCTION Sepsis, characterized by a systemic inflammatory response syndrome resulting from infection, remains a significant health concern with ICU mortality rates ranging from 6% to 30%, escalating to over 40% in patients with septic shock.1, 2 Currently, there is a lack of reliable prognostic indicators for critically ill patients with infections, leading to a dearth of targeted interventions and treatment strategies.

May 28, 2024 | beyondchron.org | Dan Xie

PIRG’s Building Student PowerWhen we say civic engagement means engaging young people year-round beyond elections, we mean it. This year, PIRG clubs and chapters across the country worked to make sure student voices were heard on more than a dozen issue areas ranging from conserving critical habitats for future generations to making voting more accessible to students and protecting students from textbook publishing industry abuses.

Apr 1, 2024 | nature.com | Dan Xie

AbstractRNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in colorectal cancer (CRC) are still lacking. Processing bodies (PBs) formed through liquid-liquid phase separation (LLPS) are membrane-less organelles (MLOs) consisting of RBPs and RNA. Previous evidence suggests a connection between PBs dynamics and cancer progression.