Dane Cheasley

Jan 9, 2025 | nature.com | Deepak N Subramanian |Lisa Devereux |Dane Cheasley |Paul James

AbstractHigh-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component, only half of which is explained. Previously, we performed germline exome sequencing on BRCA1 and BRCA2-negative HGSOC patients, revealing three proposed and 43 novel candidate genes enriched with rare loss-of-function variants. For validation, we undertook case-control analyses using genomic data from disease-free controls. This confirms enrichment for nearly all previously identified genes.