Lisa Devereux

Jan 9, 2025 | nature.com | Deepak N Subramanian |Lisa Devereux |Dane Cheasley |Paul James

AbstractHigh-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component, only half of which is explained. Previously, we performed germline exome sequencing on BRCA1 and BRCA2-negative HGSOC patients, revealing three proposed and 43 novel candidate genes enriched with rare loss-of-function variants. For validation, we undertook case-control analyses using genomic data from disease-free controls. This confirms enrichment for nearly all previously identified genes.

Feb 27, 2023 | nature.com | Madelynne O. Willis |Allison Hunt |Ahwan Pandey |Tamara Abulez |Sian Fereday |Dale W. Garsed | +10 more

AbstractHigh-grade serous ovarian cancer (HGSC) is frequently characterized by homologous recombination (HR) DNA repair deficiency and, while most such tumors are sensitive to initial treatment, acquired resistance is common. We undertook a multiomics approach to interrogate molecular diversity in end-stage disease, using multiple autopsy samples collected from 15 women with HR-deficient HGSC.

Feb 27, 2023 | go.nature.com | Madelynne O. Willis |Allison Hunt |Ahwan Pandey |Tamara Abulez |Sian Fereday |Dale W. Garsed | +10 more

AbstractHigh-grade serous ovarian cancer (HGSC) is frequently characterized by homologous recombination (HR) DNA repair deficiency and, while most such tumors are sensitive to initial treatment, acquired resistance is common. We undertook a multiomics approach to interrogate molecular diversity in end-stage disease, using multiple autopsy samples collected from 15 women with HR-deficient HGSC.