Deepak N Subramanian

Jan 9, 2025 | nature.com | Deepak N Subramanian |Lisa Devereux |Dane Cheasley |Paul James

AbstractHigh-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component, only half of which is explained. Previously, we performed germline exome sequencing on BRCA1 and BRCA2-negative HGSOC patients, revealing three proposed and 43 novel candidate genes enriched with rare loss-of-function variants. For validation, we undertook case-control analyses using genomic data from disease-free controls. This confirms enrichment for nearly all previously identified genes.

Nov 21, 2024 | nature.com | Deepak N Subramanian |Carol Eisenberg |Andrew Huang |Jiyeon Baek |Michael W. Shiflett |Tracy Tran

AbstractDysregulation of development, migration, and function of interneurons, collectively termed interneuronopathies, have been proposed as a shared mechanism for autism spectrum disorders (ASDs) and childhood epilepsy. Neuropilin-2 (Nrp2), a candidate ASD gene, is a critical regulator of interneuron migration from the median ganglionic eminence (MGE) to the pallium, including the hippocampus.

Feb 6, 2024 | biorxiv.org | Deepak N Subramanian |Carol Eisenberg |Andrew 'bunnie' Huang |Jiyeon Baek

AbstractDysregulation of development, migration, and function of interneurons, collectively termed interneuronopathies, have been proposed as a shared mechanism for autism spectrum disorders (ASDs) and childhood epilepsy. Neuropilin-2 (Nrp2), a candidate ASD gene, is a critical regulator of interneuron migration from the median ganglionic eminence (MGE) to the pallium, including the hippocampus.