Daniel Asarnow

Jan 15, 2025 | biorxiv.org | Risako Gen |Amin Addetia |Daniel Asarnow |Young-Jun Park

AbstractSARS-CoV-2 nonstructural protein 1 (nsp1) promotes innate immune evasion by inhibiting host translation in human cells. However, the role of nsp1 in other host species remains elusive, especially in bats which are natural reservoirs of sarbecoviruses and possess a markedly different innate immune system than humans. Here, we reveal that SARS-CoV-2 nsp1 potently inhibits translation in bat cells from Rhinolophus lepidus, belonging to the same genus as known sarbecovirus reservoirs hosts.

Apr 1, 2024 | biorxiv.org | Young-Jun Park |Daniel Asarnow |Megi Rexhepaj |Lisa Perruzza

AbstractPorcine deltacoronavirus (PDCoV) spillovers were recently detected in children with acute undifferentiated febrile illness, underscoring recurrent zoonoses of divergent coronaviruses. To date, no vaccines or specific therapeutics are approved for use in humans against PDCoV.