Lisa Perruzza

1 month ago | biorxiv.org | Amin Addetia |Lisa Perruzza |Young-Jun Park |Matthew McCallum

AbstractMarburg virus (MARV) is a filovirus that causes a severe and often lethal hemorrhagic fever. Despite the increasing frequency of MARV outbreaks, no vaccines or therapeutics are licensed for use in humans. Here, we designed mutations that improve the expression and thermostability of the prefusion MARV glycoprotein (GP) ectodomain trimer, which is the sole target of neutralizing antibodies and vaccines in development.

Apr 1, 2024 | biorxiv.org | Young-Jun Park |Daniel Asarnow |Megi Rexhepaj |Lisa Perruzza

AbstractPorcine deltacoronavirus (PDCoV) spillovers were recently detected in children with acute undifferentiated febrile illness, underscoring recurrent zoonoses of divergent coronaviruses. To date, no vaccines or specific therapeutics are approved for use in humans against PDCoV.