Daniel Castro

Feb 16, 2024 | nature.com | Yuxuan Xie |Daniel Castro |Stanislav S. Rubakhin |Jonathan V. Sweedler

AbstractSpatial omics technologies can reveal the molecular intricacy of the brain. While mass spectrometry imaging (MSI) provides spatial localization of compounds, comprehensive biochemical profiling at a brain-wide scale in three dimensions by MSI with single-cell resolution has not been achieved. We demonstrate complementary brain-wide and single-cell biochemical mapping using MEISTER, an integrative experimental and computational mass spectrometry (MS) framework.