Yi Lin

1 month ago | nature.com | Oren Pasvolsky |Lei Feng |James Davis |Aimaz Afrough |Mariola Vazquez-Martinez |Utkarsh Goel | +22 more

AbstractTeclistamab, a BCMA-directed bispecific antibody, received regulatory approval for relapsed/refractory multiple myeloma (RRMM) based on the MajesTEC-1 study. Despite the fact that myeloma is primarily a cancer of elderly adults, only 15% of MajesTEC-1 participants (n = 24) were ≥75 years old. In this multicenter retrospective study, we report real-world outcomes of a large cohort of older RRMM patients treated with teclistamab.

1 month ago | nature.com | Moritz Binder |Joselle M. Cook |Prashant Kapoor |Taxiarchis Kourelis |Shaji Kumar |Mustaqeem Siddiqui | +1 more

AbstractChanges in metabolic activity in tumor cells is one of the hallmarks of cancer. Cancer cells exhibit the Warburg effect with high glucose consumption for their energy needs. This provides the basis for imaging using 18F-2-deoxy-D-glucose for positron emission tomography to assess tumor burden and response to therapy.

Mar 19, 2025 | nature.com | Bijal Shah |Ryan D. Cassaday |Jae Park |Nicolas Boissel |Yi Lin |Gary Schiller | +5 more

AbstractBrexucabtagene autoleucel (brexu-cel) is an autologous anti-CD19 CAR T-cell therapy approved in the US to treat adults aged ≥18 years (≥26 years in the EU) with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). Brexu-cel showed an overall complete remission (CR)/CR with incomplete hematologic recovery (CRi) rate of 73% (CR rate 60%) and median overall survival (OS) of 25.4 months in 78 patients with R/R B-ALL after 2 years in ZUMA-3.

Jan 8, 2025 | pubs.rsc.org | Yi Lin |Hang Lin |Bo Wang |Gaoming Dong

Ca2YScAl2Si2O12:Cr3+ phosphor-in-glass film for laser-driven high-power near-infrared lighting The rise of laser diode (LD)-driven phosphor-converted near-infrared (NIR) lighting sources, offering unparalleled advantages in terms of brightness and imaging resolution, is hindered by a scarcity of color converters possessing desired properties.

Dec 4, 2024 | onlinelibrary.wiley.com | Bo Wang |Jianing Xu |Yi Lin |Chengyi Xiao

1 Introduction Organic solar cells (OSCs) have attracted significant attention in recent years due to their unique advantages, including flexibility, lightweight design, solution-processability, and semitransparency.[1] These attributes make OSCs promising for a wide range of applications, such as the Internet of Things, indoor photovoltaics, smart windows, and more.[2] The development of innovative electron acceptors, particularly those replacing fullerene derivatives, has been pivotal in...