Daniel E. Coral

Oct 24, 2024 | nature.com | Daniel E. Coral |Alexander Gieswinkel |Kan Wang |Marinella Temprosa |Jose Manuel Fernández-Real |M. Kamran Ikram | +11 more

AbstractObesity and cardiometabolic disease often, but not always, coincide. Distinguishing subpopulations within which cardiometabolic risk diverges from the risk expected for a given body mass index (BMI) may facilitate precision prevention of cardiometabolic diseases. Accordingly, we performed unsupervised clustering in four European population-based cohorts (N ≈ 173,000).

Sep 25, 2024 | nature.com | Paul W. Franks |Daniel E. Coral

In this issue of Nature Metabolism, Carrasco-Zanini et al. describe sets of modifiable and non-modifiable drivers of human plasma proteins. These findings may inform the design of precision prevention programs and highlight novel therapeutic targets.

Feb 23, 2023 | nature.com | Daniel E. Coral |Paul W. Franks

By measuring protein abundance in blood using high-throughput antibody-based techniques, a genetic map of blood proteins in humans replicates findings from much larger studies, uncovers hundreds of new signals and bridges genetic variation to multiple diseases. A study by Koprulu et al.1 published in this issue of Nature Metabolism provides an excellent example of a carefully conducted epidemiological study within which detailed proteogenomic analyses have been performed.