Paul W. Franks

Nov 21, 2024 | nature.com | Paul W. Franks

Sep 25, 2024 | nature.com | Paul W. Franks |Daniel E. Coral

In this issue of Nature Metabolism, Carrasco-Zanini et al. describe sets of modifiable and non-modifiable drivers of human plasma proteins. These findings may inform the design of precision prevention programs and highlight novel therapeutic targets.

Aug 21, 2023 | nature.com | Andrew Brown |Mun-Gwan Hong |Robert Caiazzo |Giuseppe Giordano |Mark Haid |Torben Frøstrup Hansen | +17 more

AbstractWe evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions.

May 3, 2023 | nature.com | Roderick C. Slieker |Eleni Georgiadou |Giuseppe Giordano |Emma Ahlqvist |Ashfaq Ansari Ali |Karina Banasik | +22 more

Discovery cohorts Summary statistics of lipidomic, proteomic and metabolomic data is available from a Shiny dashboard available from: https://rhapdata-app.vital-it.ch. The generated metabolomic, lipidomic and proteomic data in DCS, GoDARTS and ANDIS are considered sensitive patient data and can therefore not be publicly available in compliance with the European privacy regulations governed by GDPR and according to limitations included in the informed consents signed by the study participants.

Feb 23, 2023 | nature.com | Daniel E. Coral |Paul W. Franks

By measuring protein abundance in blood using high-throughput antibody-based techniques, a genetic map of blood proteins in humans replicates findings from much larger studies, uncovers hundreds of new signals and bridges genetic variation to multiple diseases. A study by Koprulu et al.1 published in this issue of Nature Metabolism provides an excellent example of a carefully conducted epidemiological study within which detailed proteogenomic analyses have been performed.