Daniel Nesbitt

3 weeks ago | cell.com | Jessica Davidson |Raghav Jain |Thomas Kizzar |Gisela Geoghegan |Daniel Nesbitt |Amy Cavanagh | +20 more

Keywordslysosomelipidomicslivercold exposureliquid chromatography-mass spectrometryLC-MStranscription factor EBTFEBphospholipase A2 G15Pla2g15bis(monoacylglycero)phosphateBMPIntroductionThe liver maintains energy homeostasis in mammals by acting as a metabolic transistor switching between providing glucose or lipids for peripheral tissue catabolism. In the fed state, the liver is a sink for excess glucose to maintain normoglycemia.

Nov 10, 2023 | biorxiv.org | Raghav Jain |Gisela Geoghegan |Jessica Davidson |Daniel Nesbitt

AbstractCold exposure is an environmental stress that elicits a rapid metabolic shift in endotherms and is required for survival. The liver provides metabolic flexibility through its ability to rewire lipid metabolism to respond to an increased demand in energy for thermogenesis.

Nov 3, 2023 | biorxiv.org | Raghav Jain |Gisela Geoghegan |Jessica Davidson |Daniel Nesbitt

AbstractCold exposure is an environmental stress that elicits a rapid metabolic shift in endotherms and is required for survival. The liver provides metabolic flexibility through its ability to rewire lipid metabolism to respond to an increased demand in energy for thermogenesis.