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3 weeks ago | 00253-0?rss=yes&sz=64)
cell.com | Jessica Davidson |Raghav Jain |Thomas Kizzar |Gisela Geoghegan |Daniel Nesbitt |Amy Cavanagh | +20 more
Keywordslysosomelipidomicslivercold exposureliquid chromatography-mass spectrometryLC-MStranscription factor EBTFEBphospholipase A2 G15Pla2g15bis(monoacylglycero)phosphateBMPIntroductionThe liver maintains energy homeostasis in mammals by acting as a metabolic transistor switching between providing glucose or lipids for peripheral tissue catabolism. In the fed state, the liver is a sink for excess glucose to maintain normoglycemia.
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Nov 7, 2024 | 
journals.plos.org | Isabella James |Raghav Jain |Gina Wade |Philip Stevenson
Loading metrics Open Access Peer-reviewedResearch Article Citation: James I, Jain R, Wade G, Stevenson PC, Koulman A, Simcox J, et al. (2024) Systemic analysis shows that cold exposure modulates triglyceride accumulation and phospholipid distribution in mice. PLoS ONE 19(11): e0313205. https://doi.org/10.1371/journal.pone.0313205Editor: Stephan N.
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Apr 22, 2024 | 
elifesciences.org | Venkateshwari Varadharajan |Iyappan Ramachandiran |William Massey |Raghav Jain
eLife assessment Varadharajan et al. explore the mechanistic basis of MBOAT7 SNP association with steatotic liver disease and link its function in LPI acylation to altered lipidomics of endosomal/lysosomal system and impaired TFEB mediated lysosomal biogenesis. The findings are important with theoretical and practical implications in MAFLD, alcohol-induced hepatic steatosis, and lysosomal diseases. The strength of evidence is convincing using methodology in line with current state-of-the-art.
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Nov 10, 2023 | 
biorxiv.org | Raghav Jain |Gisela Geoghegan |Jessica Davidson |Daniel Nesbitt
AbstractCold exposure is an environmental stress that elicits a rapid metabolic shift in endotherms and is required for survival. The liver provides metabolic flexibility through its ability to rewire lipid metabolism to respond to an increased demand in energy for thermogenesis.
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Nov 3, 2023 | 
biorxiv.org | Raghav Jain |Gisela Geoghegan |Jessica Davidson |Daniel Nesbitt
AbstractCold exposure is an environmental stress that elicits a rapid metabolic shift in endotherms and is required for survival. The liver provides metabolic flexibility through its ability to rewire lipid metabolism to respond to an increased demand in energy for thermogenesis.
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Oct 26, 2023 | 
argusmedia.com | Raghav Jain
European stainless steel scrap prices are poised to fall further from an already-low level in the near term on the twin forces of reduced domestic mill production and declining prices in major export markets in Asia, trading firms told Argus on the sidelines of the Bureau of International Recycling convention in Abu Dhabi on 23-24 October. "Prices could test levels not seen since the early stages of the [Covid-19] pandemic," a German trading company said.
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Sep 27, 2023 | 
biorxiv.org | William Massey |Raghav Jain |Venkateshwari Varadharajan |Iyappan Ramachandiran
AbstractSeveral recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound O-acyltransferase 7 (MBOAT7) that is associated with advanced liver diseases.
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Aug 2, 2023 | 
argusmedia.com | Raghav Jain
An error has occured. The article you are searching for was not found. Published date: 02 August 2023 The nickel market is bracing itself for a wave of new Class 1 supply, with the resulting increase in London Metal Exchange (LME) stocks likely to widen the structural market surplus and drive benchmark prices down.
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Jul 4, 2023 | 
argusmedia.com | Raghav Jain
An error has occured. The article you are searching for was not found. Published date: 04 July 2023 Nickel prices on the London Metal Exchange (LME) dipped below $20,000/t for the first time in nearly 12 months towards the end of June, as subdued demand-side fundamentals in the world's major economies combined with still-growing Indonesian supply to drive a sharp sell-off this year.
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Jun 22, 2023 | 
argusmedia.com | Raghav Jain
An error has occured. The article you are searching for was not found. Published date: 22 June 2023 The London Metal Exchange (LME) was aware of an incident involving Chinese nickel and stainless steel giant Tsingshan's use of the over-the-counter (OTC) trading market back in 2019, LME chief executive Matthew Chamberlain told London's High Court today as part of his witness statement.
