Daniel Oehler

Aug 22, 2024 | nature.com | Selene Lickfett |Agnieszka Rybak-Wolf |Carmen Menacho |Stephanie Le |Tancredi Massimo Pentimalli |Daniel Oehler | +14 more

AbstractExpansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic insights into the neurodevelopmental impact of human mHTT, we engineered male induced pluripotent stem cells to introduce a biallelic or monoallelic mutant 70Q expansion or to remove the poly-Q tract of HTT.

Mar 3, 2024 | nature.com | Alexander Lang |Daniel Oehler |Norbert Gerdes

AbstractGravitational changes between micro- and hypergravity cause several adaptations and alterations in the human body. Besides muscular atrophy and immune system impairment, effects on the circulatory system have been described, which can be associated with a wide range of blood biomarker changes. This study examined nine individuals (seven males, two females) during a parabolic flight campaign (PFC).

Nov 17, 2023 | onlinelibrary.wiley.com | Moritz Benjamin Immohr |Daniel Oehler |Freya Sophie Jenkins |Nikolas Kalampokas

1 INTRODUCTION Within the last decades, tremendous progress has been achieved in postoperative survival after heart transplantation (HTx).1 However, the development of cardiac allograft vasculopathy (CAV) continues to limit the long-term outcome after HTx, as it represents the main cause of long-term graft dysfunction.2-4 Although the development of CAV is multifactorial and not fully understood, it is also associated with cytomegalovirus (CMV) infections in the postoperative course.2-4 In...

Jun 19, 2023 | mdpi.com | Charlotte Müller |Jean Marc Haurand |Daniel Oehler |Jafer Haschemi

Abstract:In-hospital cardiac arrest (IHCA) is associated with high mortality and poor neurological outcomes. Our objective was to assess whether the lactate-to-albumin ratio (LAR) can predict the outcomes in patients after IHCA. We retrospectively screened 75,987 hospitalised patients at a university hospital between 2015 and 2019. The primary endpoint was survival at 30-days. Neurological outcomes were assessed at 30 days using the cerebral performance category scale.