Daniel Phillips

1 month ago | nature.com | Nellie Y. Loh |Emile Roberts |Daniel Phillips |Matt Neville |Raymond Noordam |Jonathan H Tobias | +3 more

AbstractWNT signaling plays a key role in postnatal bone formation. Individuals with gain-of-function mutations in the WNT co-receptor LRP5 exhibit increased lower-body fat mass and potentially enhanced glucose metabolism, alongside high bone mass. However, the mechanisms by which LRP5 regulates fat distribution and its effects on systemic metabolism remain unclear. This study aims to explore the role of LRP5 in adipose tissue biology and its impact on metabolism.

Dec 31, 2023 | physoc.onlinelibrary.wiley.com | Denis Noble |Daniel Phillips

The problem with Darwin and Wallace's (1858) theory of natural selection as a complete explanation for the Origin of Species is easily understood. A chance mutation affecting a single or extremely few individuals in a continuous population will be quickly diluted through interbreeding. This fact is also clear from the outcome of artificial selection. Breeders need to prevent interbreeding when they select new variants.

Nov 7, 2023 | physoc.onlinelibrary.wiley.com | Daniel Phillips |Denis Noble

Once sacrosanct and even referred to as the Second Law of Biology (Noble, 2013), ‘Weismann's barrier’, the conceptual barrier shielding germ cells from somatic influence, is now routinely challenged by reports of animals inheriting their parents' responses to lifetime experiences in taxa ranging from nematode worms (Rechavi & Lev, 2017) to insects (Maleszka, 2016; Xia & de Belle, 2017), rodents (Gapp & Bohacek, 2018; Wang et al., 2017) and even humans (Chong & Whitelaw, 2004; Wang et al., 2017).