Jonathan H Tobias

1 month ago | nature.com | Nellie Y. Loh |Emile Roberts |Daniel Phillips |Matt Neville |Raymond Noordam |Jonathan H Tobias | +3 more

AbstractWNT signaling plays a key role in postnatal bone formation. Individuals with gain-of-function mutations in the WNT co-receptor LRP5 exhibit increased lower-body fat mass and potentially enhanced glucose metabolism, alongside high bone mass. However, the mechanisms by which LRP5 regulates fat distribution and its effects on systemic metabolism remain unclear. This study aims to explore the role of LRP5 in adipose tissue biology and its impact on metabolism.