Raymond Noordam

1 month ago | nature.com | Nellie Y. Loh |Emile Roberts |Daniel Phillips |Matt Neville |Raymond Noordam |Jonathan H Tobias | +3 more

AbstractWNT signaling plays a key role in postnatal bone formation. Individuals with gain-of-function mutations in the WNT co-receptor LRP5 exhibit increased lower-body fat mass and potentially enhanced glucose metabolism, alongside high bone mass. However, the mechanisms by which LRP5 regulates fat distribution and its effects on systemic metabolism remain unclear. This study aims to explore the role of LRP5 in adipose tissue biology and its impact on metabolism.

Sep 3, 2024 | medrxiv.org | Raymond Noordam |Wenyi Wang |Pavithra Nagarajan |Heming Wang

HJG has received travel grants and speakers honoraria from Neuraxpharm, Servier, Indorsia and Janssen Cilag. LMR is a consultant for the TOPMed Administrative Coordinating Center (through Westat). TDS is co-founder and shareholder of ZOE Ltd. All other co-authors declare to have no conflicts of interest. This project was largely supported by two grants from the U.S. National Heart, Lung, and Blood Institute (NHLBI), the National Institutes of Health, R01HL118305 and R01HL156991.

Aug 27, 2024 | mdpi.com | Raymond Noordam |Marco C DeRuiter |Monique R. M |Ruben Methorst

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Mar 6, 2024 | nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more

AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.

Mar 1, 2024 | onlinelibrary.wiley.com | Raymond Noordam |Linjun Ao |Jasmijn Stroo |Leiden Laboratory

1 INTRODUCTION Sleep is a high-dimensional phenotype,1 is different for men and women, and is changing with increasing age.2 Disturbances in single dimensions of habitual sleep are increasingly recognized as important risk factors contributing to the onset of age-related diseases, including metabolic, cardiovascular and neurodegenerative diseases,3-7 COVID-19 and influenza susceptibility,8, 9 some types of cancer,10-12 and mortality.13 Mendelian randomization, which uses genetic variants...