Daniele Ramazzotti

Jan 23, 2024 | biorxiv.org | Lucie Gourmet |Daniele Ramazzotti |Parag Mallick |Simon Walker-Samuel

AbstractCancer hallmarks describe key physiological characteristics that distinguish cancers from normal tissues. The temporal order in which these hallmarks appear during cancer pathogenesis is of interest from both evolutionary and clinical perspectives but has not been investigated before. Here, we order hallmarks based on the allele frequency and selective advantage of mutations in cancer hallmark genes across >10k untreated primary tumors and >8K healthy tissues.