Parag Mallick

Mar 6, 2024 | biorxiv.org | Lucie Gourmet |Parag Mallick |Simon Walker-Samuel

AbstractThough the earliest stages of oncogenesis, post initiation, are not well understood, it is generally appreciated that a successful transition from a collection of dysregulated cells to an aggressive tumor requires complex ecological interactions between cancer cells and their environment. One key component of tumorigenesis is immune evasion. To investigate the interplay amongst the ecological behaviour of mutualism and immune evasion, we used a computational simulation framework.

Jan 23, 2024 | biorxiv.org | Lucie Gourmet |Daniele Ramazzotti |Parag Mallick |Simon Walker-Samuel

AbstractCancer hallmarks describe key physiological characteristics that distinguish cancers from normal tissues. The temporal order in which these hallmarks appear during cancer pathogenesis is of interest from both evolutionary and clinical perspectives but has not been investigated before. Here, we order hallmarks based on the allele frequency and selective advantage of mutations in cancer hallmark genes across >10k untreated primary tumors and >8K healthy tissues.