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Jul 24, 2024 | 
nature.com | Yi-Hao Chan |zhiyong Liu |Paul Bastard |Oliver Harschnitz |Peng Zhang |Gabriele Ciceri | +14 more
AbstractMost cases of herpes simplex virus 1 (HSV-1) encephalitis (HSE) remain unexplained1,2. Here, we report on two unrelated people who had HSE as children and are homozygous for rare deleterious variants of TMEFF1, which encodes a cell membrane protein that is preferentially expressed by brain cortical neurons. TMEFF1 interacts with the cell-surface HSV-1 receptor NECTIN-1, impairing HSV-1 glycoprotein D- and NECTIN-1-mediated fusion of the virus and the cell membrane, blocking viral entry.
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Feb 9, 2023 | 
science.org | Andrew Feinberg |Ryohei Iwata |Danyel Lee |James Hendler
Information & AuthorsInformationPublished In ScienceVolume 379 | Issue 663210 February 2023CopyrightCopyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Submission historyPublished in print: 10 February 2023PermissionsRequest permissions for this article.
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Feb 9, 2023 | 
science.org | Andrew Feinberg |Ryohei Iwata |Danyel Lee |Hai Hu
LATEST NEWS Nanoscale negative refractionRefraction is a familiar effect in which a light beam alters direction as it propagates from one medium to another. Negative refraction is a nonintuitive but well-established effect in which the light beam is bent in the “wrong” direction. Two groups now independently demonstrate negative refraction at the interface of two-dimensional van der Waal materials. Hu et al.
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Feb 9, 2023 | 
science.org | Andrew Feinberg |Ryohei Iwata |Danyel Lee |Ralf C. Buckley
Information & AuthorsInformationPublished In ScienceVolume 379 | Issue 663210 February 2023CopyrightCopyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Submission historyPublished in print: 10 February 2023PermissionsRequest permissions for this article.
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Feb 9, 2023 | 
science.org | Andrew Feinberg |Ryohei Iwata |Danyel Lee |Elise Parey
LATEST NEWS Debate resolved? Teleost (or “ray-finned”) fishes make up half of all vertebrates, but there has been long-standing debate about their early evolution. Using new genomes from fishes in the basal group that includes tarpons and eels, as well as approaches that integrate patterns of genome structure not just sequence, Parey et al. show that this group forms a monophyletic lineage within another group that includes the arapaima and elephant nose fishes.
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Feb 9, 2023 | 
science.org | Andrew Feinberg |Ryohei Iwata |Danyel Lee |Victor Penchaszadeh
eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. eLetters are not edited, proofread, or indexed. Please read our Terms of Service before submitting your own eLetter.
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Feb 9, 2023 | 
science.org | Andrew Feinberg |Ryohei Iwata |Danyel Lee |Larissa Dietz
LATEST NEWS AbstractCertain Inhibitors of apoptosis (IAP) family members are sentinel proteins preventing untimely cell death by inhibiting caspases. Antagonists including second mitochondria-derived activator of caspase (SMAC) regulate IAPs, driving cell death. Baculoviral IAP repeat-containing protein 6 (BIRC6), a giant IAP with dual E2/E3 ubiquitin ligase activity, regulates programmed cell death through unknown mechanisms.
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Feb 9, 2023 | 
science.org | Andrew Feinberg |Ryohei Iwata |Danyel Lee |Yuta Tsukamoto
LATEST NEWS Catching out cap snatchingSome virus families hijack part of their hosts’ RNA to enable their own replication in a process called cap snatching. Before they can enact a snatch, influenza viruses specifically require host cap maturation by a host methyltransferase called MTr1. Tsukamoto et al. screened a compound library and found that trifluoromethyl-tubercidin (TFMT) inhibits host Mtr1 and suppresses virus replication.
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Feb 9, 2023 | 
science.org | Andrew Feinberg |Ryohei Iwata |Danyel Lee |Viktor Mayer-Schönberger
Information & AuthorsInformationPublished In ScienceVolume 379 | Issue 663210 February 2023CopyrightCopyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Submission historyPublished in print: 10 February 2023PermissionsRequest permissions for this article.
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Feb 9, 2023 | 
science.org | Andrew Feinberg |Ryohei Iwata |Danyel Lee |Shirley M. Malcom
A slow-motion crisis is underway among graduate students and postdocs in the United States who comprise today’s indispensable research and teaching workforce and tomorrow’s scientific leaders. Low pay, lack of benefits, and sometimes toxic research environments have persisted for years. Frustrated graduate students, postdocs, and nontenured faculty are protesting and pursuing unionization to address worsening conditions.
