Gabriele Ciceri

Sep 1, 2024 | nature.com | Juliane Tschuck |Gabriele Ciceri |Jason Tchieu |Brent R. Stockwell |Lorenz Studer |Michael P. Menden | +1 more

AbstractThe development of functional neurons is a complex orchestration of multiple signaling pathways controlling cell proliferation and differentiation. Because the balance of antioxidants is important for neuronal survival and development, we hypothesized that ferroptosis must be suppressed to gain neurons.

Jul 24, 2024 | nature.com | Yi-Hao Chan |zhiyong Liu |Paul Bastard |Oliver Harschnitz |Peng Zhang |Gabriele Ciceri | +14 more

AbstractMost cases of herpes simplex virus 1 (HSV-1) encephalitis (HSE) remain unexplained1,2. Here, we report on two unrelated people who had HSE as children and are homozygous for rare deleterious variants of TMEFF1, which encodes a cell membrane protein that is preferentially expressed by brain cortical neurons. TMEFF1 interacts with the cell-surface HSV-1 receptor NECTIN-1, impairing HSV-1 glycoprotein D- and NECTIN-1-mediated fusion of the virus and the cell membrane, blocking viral entry.

May 21, 2024 | nature.com | Hermany Munguba |Arianna Baggiolini |Conor Liston |Shuibing Chen |Gabriele Ciceri

Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-023-02031-z, published online 2 January 2024. In Fig. 3h–k we recorded spontaneous excitatory postsynaptic currents (sEPSCs) in human PSC-derived cortical neurons at either –60 mV or at 0 mV, comparing their synaptic properties following GENtoniK versus DMSO treatment. We reported those currents as either “AMPAR”- or “NMDAR”-mediated, respectively.

Jan 31, 2024 | nature.com | Gabriele Ciceri |Arianna Baggiolini |Hyein Cho |Alberto J Gonzalez-Hernandez |Hermany Munguba |So Yeon Koo | +3 more

AbstractThe pace of human brain development is highly protracted compared with most other species1,2,3,4,5,6,7. The maturation of cortical neurons is particularly slow, taking months to years to develop adult functions3,4,5. Remarkably, such protracted timing is retained in cortical neurons derived from human pluripotent stem cells (hPSCs) during in vitro differentiation or upon transplantation into the mouse brain4,8,9.

Jan 1, 2024 | nature.com | Hermany Munguba |Arianna Baggiolini |Conor Liston |Shuibing Chen |Gabriele Ciceri

AbstractThe maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the protracted timing of human brain development, extending over months to years for reaching adult-like function. Prolonged in vitro maturation presents a major challenge to stem cell-based applications in modeling and treating neurological disease.