Danyue Li

Jun 12, 2024 | biorxiv.org | Xinyu Fu |Weilv Xu |Danyue Li |Xinyue Li

AbstractViral infection triggers inflammasome-mediated caspase-1 activation. Nevertheless, limited understanding exists regarding how viruses use the active caspase-1 to evade host immune response. Here, we use porcine epidemic diarrhea virus (PEDV) as a model of coronaviruses (CoVs) to illustrate the intricate regulation of CoVs to combat IFN-I signaling and pyroptosis.

Feb 6, 2024 | nature.com | Weilv Xu |Qiao Jin |Xinyue Li |Danyue Li |Xinyu Fu |Nan Chen | +4 more

AbstractGasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely unexplored. In this study, we demonstrate that GSDMD can undergo acetylation at the Lysine 248 residue, and this acetylation enhances pyroptosis.

Jun 6, 2023 | biorxiv.org | Xinyue Li |Xinyu Fu |Weilv Xu |Danyue Li

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