Xinyu Fu

Jun 12, 2024 | biorxiv.org | Xinyu Fu |Weilv Xu |Danyue Li |Xinyue Li

AbstractViral infection triggers inflammasome-mediated caspase-1 activation. Nevertheless, limited understanding exists regarding how viruses use the active caspase-1 to evade host immune response. Here, we use porcine epidemic diarrhea virus (PEDV) as a model of coronaviruses (CoVs) to illustrate the intricate regulation of CoVs to combat IFN-I signaling and pyroptosis.

Feb 6, 2024 | nature.com | Weilv Xu |Qiao Jin |Xinyue Li |Danyue Li |Xinyu Fu |Nan Chen | +4 more

AbstractGasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely unexplored. In this study, we demonstrate that GSDMD can undergo acetylation at the Lysine 248 residue, and this acetylation enhances pyroptosis.

Sep 4, 2023 | dailybulletin.com.au | Xinyu Fu

Despite countries pouring billions of dollars into “protecting” communities, flood-related disasters are becoming more frequent and are projected to become even more severe as the climate crisis worsens. In fact, many areas that flooded during recent extreme weather events, from Auckland to Henan in China, were deemed to be relatively safe. This should raise an obvious question: to what extent is our existing approach fit for purpose in a changing climate?

Jun 6, 2023 | biorxiv.org | Xinyue Li |Xinyu Fu |Weilv Xu |Danyue Li

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