Daoyuan Qian

Aug 19, 2024 | biorxiv.org | Nadia Aicha Erkamp |Mina S. Farag |Yuanxin Qiu |Daoyuan Qian

AbstractBiomolecular condensates form via macromolecular phase separation, giving rise to coexisting phases delineated by interfaces. Here, we characterize the structures of interfaces formed by phase separation driven by heterotypic interactions in ternary mixtures of two types of RNA molecules and polyethylene glycol. We find that purine-rich RNAs are scaffolds that drive phase separation via strong heterotypic interactions.

Jun 27, 2023 | nature.com | Daoyuan Qian |Michele Vendruscolo |Sara Linse

Cite this articleMichaels, T.C.T., Qian, D., Šarić, A. et al. Amyloid formation as a protein phase transition. Nat Rev Phys (2023). https://doi.org/10.1038/s42254-023-00598-9Download citationAccepted: 12 May 2023Published: 27 June 2023DOI: https://doi.org/10.1038/s42254-023-00598-9Share this articleAnyone you share the following link with will be able to read this content:Sorry, a shareable link is not currently available for this article.