Nadia Aicha Erkamp

Sep 25, 2024 | biorxiv.org | Tuomas Knowles |Yihan Yao |Nadia Aicha Erkamp |Tomas Sneideris

AbstractThyroid hormones are produced by the thyroid gland and are essential for regulating metabolism, growth and development. Maintenance of circulating thyroid hormone levels within an appropriate range is thus a prerequisite for health. In vivo, this objective is, at least in part, facilitated through an extracellular storage depot of thyroglobulin, the glycoprotein precursor for thyroid hormones, in the thyroid follicular lumen.

Aug 19, 2024 | biorxiv.org | Nadia Aicha Erkamp |Mina S. Farag |Yuanxin Qiu |Daoyuan Qian

AbstractBiomolecular condensates form via macromolecular phase separation, giving rise to coexisting phases delineated by interfaces. Here, we characterize the structures of interfaces formed by phase separation driven by heterotypic interactions in ternary mixtures of two types of RNA molecules and polyethylene glycol. We find that purine-rich RNAs are scaffolds that drive phase separation via strong heterotypic interactions.