David Andrijevic

Jan 15, 2025 | nature.com | Navjot Kaur |David Andrijevic |Shaojie Ma |Thomas S Klarić |Megan Burke |Markus Moser | +6 more

AbstractThe ventrolateral pallial (VLp) excitatory neurons in the claustro-amygdalar complex and piriform cortex (PIR; which forms part of the palaeocortex) form reciprocal connections with the prefrontal cortex (PFC), integrating cognitive and sensory information that results in adaptive behaviours1,2,3,4,5. Early-life disruptions in these circuits are linked to neuropsychiatric disorders4,5,6,7,8, highlighting the importance of understanding their development.

May 17, 2024 | nature.com | Brian D. Piening |Maedeh Mohebnasab |Bo Xia |Jeffrey S. Stern |Weimin Zhang |Jacqueline I. Kim | +20 more

AbstractIn a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand the detailed molecular landscape following xenotransplantation, we carried out bulk and single-cell transcriptomics, lipidomics, proteomics and metabolomics on blood samples obtained from the transplanted decedents every 6 h, as well as histological and transcriptomic tissue profiling.