David Bennett

Jan 15, 2025 | cell.com | Han Zhang |Dylan Deska-Gauthier |Colin Mackay |Joanna Borowska-Fielding |Vladimir Rancic |Turgay Akay | +6 more

Keywords spinal cord V3 Sim1 interneuron locomotor circuit motor output gain Research topic(s) CP: Neuroscience Introduction The generation of coordinated movement involves an intricate interplay between the brain, spinal cord, muscles, and limbs, allowing animals to perform a wide range of movements, from reflexive responses to complex voluntary actions.1,2 At the heart of this system is the spinal cord, a critical hub for transmitting neural signals between the brain and body, orchestrating...

Apr 25, 2024 | biorxiv.org | Matthew Taylor |SYED AHMED |Ellena G Badenoch |David Bennett

AbstractTwo processes held in delicate balance during the fine tuning of synapse development are oxidative stress and autophagy: each can promote synapse expansion yet in excess are toxic. How this balance is maintained is not fully understood. While ataxia-telangiectasia mutated (ATM) is recognized as a key regulator of the DNA damage response, there is increasing evidence of a neuronal-specific role for this ubiquitous kinase and deficiency causes early-onset neurodegeneration.