Ellena G Badenoch

Apr 25, 2024 | biorxiv.org | Matthew Taylor |SYED AHMED |Ellena G Badenoch |David Bennett

AbstractTwo processes held in delicate balance during the fine tuning of synapse development are oxidative stress and autophagy: each can promote synapse expansion yet in excess are toxic. How this balance is maintained is not fully understood. While ataxia-telangiectasia mutated (ATM) is recognized as a key regulator of the DNA damage response, there is increasing evidence of a neuronal-specific role for this ubiquitous kinase and deficiency causes early-onset neurodegeneration.