David Drechsel

Oct 22, 2024 | biorxiv.org | Raman van Wee |Yiwen Li |David Drechsel |Maria Popova

AbstractDNA loop extrusion by cohesin has emerged as a critical pathway for chromosome organization. In vitro single-molecule experiments indicate that loop extrusion requires the assembly of an heteropentameric complex consisting of the SMC1/SMC3 heterodimer, STAG1, NIPBL and the kleisin SCC1.